PHLDA2

This gene is one of several genes in the imprinted gene domain of 11p15.5 which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth. [provided by RefSeq]

Full Name

pleckstrin homology-like domain, family A, member 2

Function

Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity).

Biological Process

Animal organ morphogenesisIEA:Ensembl
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Placenta developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of apoptotic processIEA:InterPro
Regulation of cell migrationIEA:Ensembl
Regulation of embryonic developmentIEA:Ensembl
Regulation of gene expressionIEA:Ensembl
Regulation of glycogen metabolic processIEA:Ensembl
Regulation of growth hormone activityIEA:Ensembl
Regulation of spongiotrophoblast cell proliferationIEA:Ensembl

Cellular Location

Cytoplasm
Membrane