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Mouse Anti-PHLDA2 Recombinant Antibody (5E3) (CBMAB-P1694-YC)

Provided herein is a Mouse monoclonal antibody against Human Pleckstrin Homology Like Domain Family A Member 2. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PHLDA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5E3
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
PHLDA2 (NP_003302, 1-110 aa) partial recombinant protein with GST tag. Immunogen sequence: MKSPDEVLRE GELEKRSDSL FQLWKKKRGV LTSDRLSLFP ASPRARPKEL RFHSILKVDC VERTGKYVYF TIVTTDHKEI DFRCAGESCW NAAIALALID FQNRRALQDF
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-110

Target

Full Name
pleckstrin homology-like domain, family A, member 2
Introduction
PHLDA2 is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.
Entrez Gene ID
UniProt ID
Alternative Names
Pleckstrin Homology Like Domain Family A Member 2; Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 3 Protein; Beckwith-Wiedemann Syndrome Chromosomal Region 1 Candidate Gene C Protein; Tumor Suppressing Subtransferable Candidate 3; Imprinted In Placenta And Liver Protein; P17-Beckwith-Wiedemann Region 1 C; P17-BWR1C; TSSC3; BWR1C; HLDA2;
Function
Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity).
Biological Process
Animal organ morphogenesisIEA:Ensembl
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Placenta developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of apoptotic processIEA:InterPro
Regulation of cell migrationIEA:Ensembl
Regulation of embryonic developmentIEA:Ensembl
Regulation of gene expressionIEA:Ensembl
Regulation of glycogen metabolic processIEA:Ensembl
Regulation of growth hormone activityIEA:Ensembl
Regulation of spongiotrophoblast cell proliferationIEA:Ensembl
Cellular Location
Cytoplasm
Membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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