Mouse Anti-PHLDA2 Recombinant Antibody (5E3) (CBMAB-P1694-YC)

Name: Mouse Anti-PHLDA2 Recombinant Antibody (5E3)
SKU: CBMAB-P1694-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

5E3

Application

ELISA, WB

Immunogen

PHLDA2 (NP_003302, 1-110 aa) partial recombinant protein with GST tag. Immunogen sequence: MKSPDEVLRE GELEKRSDSL FQLWKKKRGV LTSDRLSLFP ASPRARPKEL RFHSILKVDC VERTGKYVYF TIVTTDHKEI DFRCAGESCW NAAIALALID FQNRRALQDF

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-110

More Infomation

Target

Full Name

pleckstrin homology-like domain, family A, member 2

Introduction

PHLDA2 is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.

Entrez Gene ID

7262

UniProt ID

Q53GA4

Alternative Names

Pleckstrin Homology Like Domain Family A Member 2; Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 3 Protein; Beckwith-Wiedemann Syndrome Chromosomal Region 1 Candidate Gene C Protein; Tumor Suppressing Subtransferable Candidate 3; Imprinted In Placenta And Liver Protein; P17-Beckwith-Wiedemann Region 1 C; P17-BWR1C; TSSC3; BWR1C; HLDA2;

Function

Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity).

Biological Process

Animal organ morphogenesisIEA:Ensembl
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Placenta developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of apoptotic processIEA:InterPro
Regulation of cell migrationIEA:Ensembl
Regulation of embryonic developmentIEA:Ensembl
Regulation of gene expressionIEA:Ensembl
Regulation of glycogen metabolic processIEA:Ensembl
Regulation of growth hormone activityIEA:Ensembl
Regulation of spongiotrophoblast cell proliferationIEA:Ensembl

Cellular Location

Cytoplasm
Membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PHLDA2 Recombinant Antibody (CBYJT-1548) (CAT#: CBMAB-T0583-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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