Phospho-CDC37 (Ser13)

CDC37 (Cell Division Cycle 37) is a Protein Coding gene. Among its related pathways are Aryl Hydrocarbon Receptor and Signaling by Ligand-Responsive EGFR Variants in Cancer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and kinase binding. An important paralog of this gene is CDC37L1.

Full Name

Cell Division Cycle 37

Function

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233).
Inhibits HSP90AA1 ATPase activity (PubMed:23569206).

Biological Process

ERBB2 signaling pathway Source: Reactome
Positive regulation of mitophagy in response to mitochondrial depolarization Source: Ensembl
Posttranscriptional regulation of gene expression Source: Ensembl
Protein folding Source: GO_Central
Protein stabilization Source: GO_Central
Protein targeting Source: ProtInc
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Regulation of interferon-gamma-mediated signaling pathway Source: MGI
Regulation of necroptotic process Source: Reactome
Regulation of type I interferon-mediated signaling pathway Source: MGI

Cellular Location

Cytoplasm

PTM

Constitutively sumoylated by UBE2I.