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Rabbit Anti-Phospho-CDC37 (Ser13) Recombinant Antibody (D8P8F) (CBMAB-CP0247-LY)

The product is antibody recognizes Phospho-CDC37 (Ser13). The antibody D8P8F immunoassay techniques such as: WB.
See all Phospho-CDC37 (Ser13) antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D8P8F
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser13 of human CDC37 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cell Division Cycle 37
Introduction
CDC37 (Cell Division Cycle 37) is a Protein Coding gene. Among its related pathways are Aryl Hydrocarbon Receptor and Signaling by Ligand-Responsive EGFR Variants in Cancer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and kinase binding. An important paralog of this gene is CDC37L1.
Entrez Gene ID
Human11140
Mouse12539
Rat114562
UniProt ID
HumanQ16543
MouseQ61081
RatQ63692
Alternative Names
Cell Division Cycle 37; CDC37 (Cell Division Cycle 37; S. Cerevisiae; Homolog); Hsp90 Chaperone Protein Kinase-Targeting Subunit; CDC37 Cell Division Cycle 37 Homolog; Hsp90 Co-Chaperone Cdc37; P50CDC37;
Function
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233).
Inhibits HSP90AA1 ATPase activity (PubMed:23569206).
Biological Process
ERBB2 signaling pathway Source: Reactome
Positive regulation of mitophagy in response to mitochondrial depolarization Source: Ensembl
Posttranscriptional regulation of gene expression Source: Ensembl
Protein folding Source: GO_Central
Protein stabilization Source: GO_Central
Protein targeting Source: ProtInc
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Regulation of interferon-gamma-mediated signaling pathway Source: MGI
Regulation of necroptotic process Source: Reactome
Regulation of type I interferon-mediated signaling pathway Source: MGI
Cellular Location
Cytoplasm
PTM
Constitutively sumoylated by UBE2I.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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