PIBF1

This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma. [provided by RefSeq, Mar 2017]

progesterone immunomodulatory binding factor 1

Plays a role in ciliogenesis.
Isoform 1
Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392).
Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211).
Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806).
Isoform 4
The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect (PubMed:14634107, PubMed:3863495, PubMed:12516630).
Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441).

Activation of Janus kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Immune system processIEA:UniProtKB-KW
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interleukin-12 productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of natural killer cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of prostaglandin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:UniProtKB
Non-motile cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to centrosomeManual Assertion Based On ExperimentIMP:UniProtKB

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm
Secreted
In progesterone-treated astrocytoma cells a 57 kDa protein and isoform 1 (90 kDa) have been described, both being located in the intracellular medium and secreted. Respective predominant forms are isoform 1 in the intracellular and the 57 kDa protein in the extracellular medium (PubMed:25218441).
Isoform 1
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Secreted
Localizes to centriolar satellites throughout the cell cycle.
Isoform 4
Secreted
Secreted by progesterone-treated lymphocytes (PubMed:14634107).

Joubert syndrome 33 (JBTS33):
A form of Joubert syndrome, a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy, renal disease, liver fibrosis, and polydactyly. JBTS33 inheritance is autosomal recessive.