Mouse Anti-PIBF1 Recombinant Antibody (CBLC250-LY) (CBMAB-C12210-LY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Isoform 1
Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392).
Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211).
Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806).
Isoform 4
The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect (PubMed:14634107, PubMed:3863495, PubMed:12516630).
Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441).
Cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Immune system processIEA:UniProtKB-KW
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interleukin-12 productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of natural killer cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of prostaglandin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:UniProtKB
Non-motile cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to centrosomeManual Assertion Based On ExperimentIMP:UniProtKB
Cytoplasm
Secreted
In progesterone-treated astrocytoma cells a 57 kDa protein and isoform 1 (90 kDa) have been described, both being located in the intracellular medium and secreted. Respective predominant forms are isoform 1 in the intracellular and the 57 kDa protein in the extracellular medium (PubMed:25218441).
Isoform 1
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Secreted
Localizes to centriolar satellites throughout the cell cycle.
Isoform 4
Secreted
Secreted by progesterone-treated lymphocytes (PubMed:14634107).
A form of Joubert syndrome, a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy, renal disease, liver fibrosis, and polydactyly. JBTS33 inheritance is autosomal recessive.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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