POLDIP2

POLDIP2 is a protein that interacts with the DNA polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions.

Full Name

DNA Polymerase Delta Interacting Protein 2

Function

Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025).
May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527).

Biological Process

Error-free translesion synthesisManual Assertion Based On ExperimentIDA:UniProtKB
Mitochondrion morphogenesisIEA:Ensembl
Mitotic spindle assemblyIEA:Ensembl
Negative regulation of macroautophagyIEA:Ensembl
Positive regulation of actin filament bindingIEA:Ensembl
Positive regulation of focal adhesion assemblyIEA:Ensembl
Positive regulation of mitotic cell cycleIEA:Ensembl
Positive regulation of mitotic cytokinesisIEA:Ensembl
Positive regulation of Rho guanyl-nucleotide exchange factor activityIEA:Ensembl
Vascular associated smooth muscle cell proliferationIEA:Ensembl

Cellular Location

Mitochondrion matrix
Nucleus
Mainly localizes to the mitochondrial matrix; a small fraction localizes in the nucleus.