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Mouse Anti-POLDIP2 Recombinant Antibody (G-10) (CBMAB-P2316-YC)

Provided herein is a Mouse monoclonal antibody against Human DNA Polymerase Delta Interacting Protein 2. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all POLDIP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
G-10
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DNA Polymerase Delta Interacting Protein 2
Introduction
POLDIP2 is a protein that interacts with the DNA polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions.
Entrez Gene ID
26073
UniProt ID
Q9Y2S7
Alternative Names
PDIP38; POLD4; p38
Function
Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025).
May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527).
Biological Process
Error-free translesion synthesisManual Assertion Based On ExperimentIDA:UniProtKB
Mitochondrion morphogenesisIEA:Ensembl
Mitotic spindle assemblyIEA:Ensembl
Negative regulation of macroautophagyIEA:Ensembl
Positive regulation of actin filament bindingIEA:Ensembl
Positive regulation of focal adhesion assemblyIEA:Ensembl
Positive regulation of mitotic cell cycleIEA:Ensembl
Positive regulation of mitotic cytokinesisIEA:Ensembl
Positive regulation of Rho guanyl-nucleotide exchange factor activityIEA:Ensembl
Vascular associated smooth muscle cell proliferationIEA:Ensembl
Cellular Location
Mitochondrion matrix
Nucleus
Mainly localizes to the mitochondrial matrix; a small fraction localizes in the nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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