PPARGC1B

PPARGC1B stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients.

Full Name

PPARG coactivator 1 beta

Function

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.

Biological Process

Actin filament organizationIEA:Ensembl
Bone trabecula formationIEA:Ensembl
Cellular response to reactive oxygen speciesIEA:Ensembl
Intracellular estrogen receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Mitochondrial transcriptionIEA:Ensembl
Negative regulation of transcription, DNA-templatedIEA:Ensembl
OssificationIEA:Ensembl
Positive regulation of alkaline phosphatase activityIEA:Ensembl
Positive regulation of bone resorptionIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of osteoclast differentiationIEA:Ensembl
Positive regulation of phosphorylationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Response to cAMPIEA:Ensembl
Response to glucocorticoidIEA:Ensembl

Cellular Location

Nucleus