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Mouse Anti-PPARGC1B Recombinant Antibody (6C3F6) (CBMAB-P2494-YC)

Provided herein is a Mouse monoclonal antibody against Human PPARG coactivator 1 beta. The antibody can be used for immunoassay techniques, such as WB, FC, ELISA, CyTOF.
See all PPARGC1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6C3F6
Antibody Isotype
IgG1
Application
WB, FC, ELISA, CyTOF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PPARG coactivator 1 beta
Introduction
PPARGC1B stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients.
Entrez Gene ID
133522
UniProt ID
Q86YN6
Alternative Names
ERRL1; PERC; PGC-1(beta); PGC1B
Function
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
Biological Process
Actin filament organizationIEA:Ensembl
Bone trabecula formationIEA:Ensembl
Cellular response to reactive oxygen speciesIEA:Ensembl
Intracellular estrogen receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Mitochondrial transcriptionIEA:Ensembl
Negative regulation of transcription, DNA-templatedIEA:Ensembl
OssificationIEA:Ensembl
Positive regulation of alkaline phosphatase activityIEA:Ensembl
Positive regulation of bone resorptionIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of osteoclast differentiationIEA:Ensembl
Positive regulation of phosphorylationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Response to cAMPIEA:Ensembl
Response to glucocorticoidIEA:Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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