PTP10D

Protein tyrosine phosphatase 10D (Ptp10D) is a transmembrane receptor tyrosine phosphatase closely related to Ptp4E. Ptp4E-Ptp10D double mutants have lethal respiratory defects. The protein may have a role in axon outgrowth and guidance. Ptp10D regulates signaling through the Egfr, btl and Pvr receptor tyrosine kinases, and binds to sas to regulate its signaling in glia.

Full Name

Ptp10D

Function

May have a role in axon outgrowth and guidance.

Biological Process

Axon guidanceManual Assertion Based On ExperimentIGI:FlyBase
Branching involved in open tracheal system developmentManual Assertion Based On ExperimentIMP:FlyBase
Central nervous system developmentManual Assertion Based On ExperimentIGI:FlyBase
Long-term memoryManual Assertion Based On ExperimentIMP:FlyBase
Motor neuron axon guidanceManual Assertion Based On ExperimentIGI:FlyBase
Negative regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIGI:FlyBase
Negative regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIGI:FlyBase
Negative regulation of vascular endothelial growth factor receptor signaling pathwayManual Assertion Based On ExperimentIGI:FlyBase
Open tracheal system developmentManual Assertion Based On ExperimentIGI:FlyBase
Protein dephosphorylationManual Assertion Based On ExperimentIDA:FlyBase

Cellular Location

Membrane

Topology

Extracellular: 43-1197
Helical: 1198-1218
Cytoplasmic: 1219-1990