PTPRG

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA.

Protein tyrosine phosphatase, receptor type G

Possesses tyrosine phosphatase activity.

Brain developmentIEA:Ensembl
Negative regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of neuron projection developmentIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc

Membrane

Extracellular: 20-736
Helical: 737-762
Cytoplasmic: 763-1445