loading...

PYGM

This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants

Full Name

phosphorylase, glycogen, muscle

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.

Biological Process

Biological Process glycogen catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glycogen metabolic processManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

cytoplasm
cytosol
extracellular exosome

Involvement in disease

Glycogen storage disease 5 (GSD5):
A metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.

PTM

Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.

View more

Anti-PYGM antibodies

+ Filters

Loading...

Mouse Anti-PYGM Recombinant Antibody (CBYC-P808) (CBMAB-P3577-YC)

Compare

Target: PYGM

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBYC-P808

Application*: E, P, WB

Mouse Anti-PYGM Recombinant Antibody (3D8) (CBMAB-P3576-YC)

Compare

Target: PYGM

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3D8

Application*: E, WB

More Infomation

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

online inquiry

Online Inquiry