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Mouse Anti-PYGM Recombinant Antibody (3D8) (CBMAB-P3576-YC)

Provided herein is a Mouse monoclonal antibody against Human Glycogen Phosphorylase, Muscle Associated. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PYGM antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3D8
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
PYGM (NP_005600.1, 734-842 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphorylase, glycogen, muscle
Introduction
PYGM is a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle.
Entrez Gene ID
5837
UniProt ID
P11217
Alternative Names
Phosphorylase, Glycogen, Muscle;Glycogen Storage Disease Type V; Myophosphorylase
Function
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
Biological Process
Biological Process glycogen catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glycogen metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
cytoplasm
cytosol
extracellular exosome
Involvement in disease
Glycogen storage disease 5 (GSD5):
A metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.
PTM
Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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