PYM1

PYM1 (PYM Homolog 1, Exon Junction Complex Associated Factor) is a protein-coding gene. Among its related pathways are RNA transport and mRNA surveillance pathway.
Full Name
PYM homolog 1, exon junction complex associated factor
Function
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.
Biological Process
Biological Process exon-exon junction complex disassemblyManual Assertion Based On ExperimentIDA:HGNC
Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of translationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Nucleus, nucleolus
Nucleus, nucleoplasm
Shuttles between the nucleus and the cytoplasm (PubMed:14968132).
Nuclear export is mediated by XPO1/CRM1 (PubMed:14968132).
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Anti-PYM1 antibodies

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Mouse Anti-PYM1 Recombinant Antibody (CBWJW-228) (CBMAB-P0016-WJ)

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Target: PYM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJW-228
Application*: IH
Datasheet SDS

Mouse Anti-PYM1 Recombinant Antibody (CBWJW-227) (CBMAB-P0017-WJ)

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Target: PYM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJW-227
Application*: IH
Datasheet SDS

Mouse Anti-PYM1 Recombinant Antibody (CBWJW-229) (CBMAB-P0015-WJ)

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Target: PYM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJW-229
Application*: IH
Datasheet SDS

Mouse Anti-PYM1 Recombinant Antibody (9C7) (CBMAB-P0007-WJ)

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Target: PYM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9C7
Application*: P
Datasheet SDS

Mouse Anti-PYM1 Recombinant Antibody (8D7) (CBMAB-P0006-WJ)

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Target: PYM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8D7
Application*: WB
Datasheet SDS

Mouse Anti-PYM1 Recombinant Antibody (2C7) (CBMAB-P0004-WJ)

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Target: PYM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C7
Application*: WB
Datasheet SDS

Mouse Anti-PYM1 Recombinant Antibody (2C1) (CBMAB-P0003-WJ)

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Target: PYM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C1
Application*: P, WB
Datasheet SDS

Mouse Anti-PYM1 Recombinant Antibody (CBWJW-205) (CBMAB-P0002-WJ)

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Target: PYM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJW-205
Application*: P, WB
Datasheet SDS

Mouse Anti-PYM1 Recombinant Antibody (11C5) (CBMAB-P0001-WJ)

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Target: PYM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 11C5
Application*: P, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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