Mouse Anti-PYM1 Recombinant Antibody (CBWJW-228) (CBMAB-P0016-WJ)

Name: Mouse Anti-PYM1 Recombinant Antibody (CBWJW-228)
SKU: CBMAB-P0016-WJ
Rating: 5 (1 reviews)

See all PYM1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJW-228

Application

IHC

Immunogen

Full length human recombinant protein of human WIBG (NP_115721) produced in HEK293T cell.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PYM homolog 1, exon junction complex associated factor

Introduction

PYM1 (PYM Homolog 1, Exon Junction Complex Associated Factor) is a protein-coding gene. Among its related pathways are RNA transport and mRNA surveillance pathway.

Entrez Gene ID

84305

UniProt ID

Q9BRP8

Alternative Names

PYM; WIBG

Function

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.

Biological Process

Biological Process exon-exon junction complex disassemblyManual Assertion Based On ExperimentIDA:HGNC
Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of translationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Nucleus, nucleolus
Nucleus, nucleoplasm
Shuttles between the nucleus and the cytoplasm (PubMed:14968132).
Nuclear export is mediated by XPO1/CRM1 (PubMed:14968132).

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-PYM1 Recombinant Antibody (CBWJW-228)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PYM1 Recombinant Antibody (2C7) (CAT#: CBMAB-P0004-WJ)

Mouse Anti-PYM1 Recombinant Antibody (CBWJW-227) (CAT#: CBMAB-P0017-WJ)

Mouse Anti-PYM1 Recombinant Antibody (8D7) (CAT#: CBMAB-P0006-WJ)

Mouse Anti-PYM1 Recombinant Antibody (CBWJW-229) (CAT#: CBMAB-P0015-WJ)

Mouse Anti-PYM1 Recombinant Antibody (9C7) (CAT#: CBMAB-P0007-WJ)

Mouse Anti-PYM1 Recombinant Antibody (11C5) (CAT#: CBMAB-P0001-WJ)

Mouse Anti-PYM1 Recombinant Antibody (2C1) (CAT#: CBMAB-P0003-WJ)

Mouse Anti-PYM1 Recombinant Antibody (CBWJW-205) (CAT#: CBMAB-P0002-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry