RAB12

RAB12 (RAB12, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB12 include Pustulosis Of Palm And Sole. Among its related pathways are Metabolism of proteins and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB10.

Full Name

RAB12, Member RAS Oncogene Family

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity).

Biological Process

AutophagyIEA:UniProtKB-KW
Cellular response to insulin stimulusManual Assertion Based On ExperimentIBA:GO_Central
Endosome to lysosome transportISS:UniProtKB
Protein catabolic processISS:UniProtKB
Protein localization to plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Rab protein signal transductionIEA:InterPro
Regulation of exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Vesicle docking involved in exocytosisManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Recycling endosome membrane
Lysosome membrane
Golgi apparatus membrane
Cytoplasmic vesicle, autophagosome

PTM

Phosphorylation of Ser-106 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.