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Mouse Anti-RAB12 Recombinant Antibody (H-11) (CBMAB-R0704-CN)

This product is a Mouse antibody that recognizes RAB12. The antibody H-11 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all RAB12 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
H-11
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
RAB12, Member RAS Oncogene Family
Introduction
RAB12 (RAB12, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB12 include Pustulosis Of Palm And Sole. Among its related pathways are Metabolism of proteins and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB10.
Entrez Gene ID
Human201475
Mouse19328
Rat25530
UniProt ID
HumanQ6IQ22
MouseP35283
RatP35284
Alternative Names
RAB12, Member RAS Oncogene Family;
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity).
Biological Process
AutophagyIEA:UniProtKB-KW
Cellular response to insulin stimulusManual Assertion Based On ExperimentIBA:GO_Central
Endosome to lysosome transportISS:UniProtKB
Protein catabolic processISS:UniProtKB
Protein localization to plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Rab protein signal transductionIEA:InterPro
Regulation of exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Vesicle docking involved in exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Recycling endosome membrane
Lysosome membrane
Golgi apparatus membrane
Cytoplasmic vesicle, autophagosome
PTM
Phosphorylation of Ser-106 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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