RABGGTB

This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]

Full Name

Rab geranylgeranyltransferase, beta subunit

Function

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

Biological Process

Biological Process protein geranylgeranylationISS:UniProtKB
Biological Process protein modification process1 PublicationNAS:UniProtKB
Biological Process protein prenylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process visual perceptionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

cytosol
plasma membrane
Rab-protein geranylgeranyltransferase complex