RAP1A

The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]

RAP1A, member of RAS oncogene family

Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.

Biological Process cellular response to cAMPManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to nerve growth factor stimulusISS:UniProtKB
Biological Process establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of synaptic vesicle exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process nerve growth factor signaling pathwayISS:UniProtKB
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process positive regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Biological Process positive regulation of GTPase activityISS:UniProtKB
Biological Process positive regulation of neuron projection developmentISS:UniProtKB
Biological Process positive regulation of protein kinase activityISS:UniProtKB
Biological Process positive regulation of vasculogenesisISS:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIDA:GO_Central
Biological Process Rap protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell junction assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of neurotransmitter receptor localization to postsynaptic specialization membraneManual Assertion Based On ExperimentIDA:SynGO
Biological Process synaptic vesicle exocytosisIEA:Ensembl

Cell membrane
Cytoplasm
Cytoplasm, perinuclear region
Cell junction
Early endosome
Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity).
Colocalized with RAPGEF2 in the perinuclear region.