Rabbit Anti-RAP1A Recombinant Antibody (26B4) (CBMAB-R1300-CN)

Name: Rabbit Anti-RAP1A Recombinant Antibody (26B4)
SKU: CBMAB-R1300-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

26B4

Application

Specificity

Human, Mouse, Rat, Monkey, Cattle

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

RAP1A, member of RAS oncogene family

Introduction

This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Entrez Gene ID

Human	5906
Mouse	109905
Rat	295347
Monkey	704404
Cattle	282031

UniProt ID

Human	P62834
Mouse	P62835
Rat	P62836
Monkey	F7GH95
Cattle	P62833

Alternative Names

RAP1A, Member Of RAS Oncogene Family; GTP-Binding Protein Smg P21A; Ras-Related Protein Krev-1; C21KG; G-22K; KREV1;

Function

Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.

Biological Process

Biological Process cellular response to cAMPManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to nerve growth factor stimulusISS:UniProtKB
Biological Process establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of synaptic vesicle exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process nerve growth factor signaling pathwayISS:UniProtKB
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process positive regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Biological Process positive regulation of GTPase activityISS:UniProtKB
Biological Process positive regulation of neuron projection developmentISS:UniProtKB
Biological Process positive regulation of protein kinase activityISS:UniProtKB
Biological Process positive regulation of vasculogenesisISS:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIDA:GO_Central
Biological Process Rap protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell junction assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of neurotransmitter receptor localization to postsynaptic specialization membraneManual Assertion Based On ExperimentIDA:SynGO
Biological Process synaptic vesicle exocytosisIEA:Ensembl

Cellular Location

Cell membrane
Cytoplasm
Cytoplasm, perinuclear region
Cell junction
Early endosome
Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity).
Colocalized with RAPGEF2 in the perinuclear region.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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