RAPGEF3
RAPGEF3 (Rap Guanine Nucleotide Exchange Factor 3) is a Protein Coding gene. Diseases associated with RAPGEF3 include Thrombocytopenia, Cyclic and Asthma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and cAMP-dependent protein kinase regulator activity. An important paralog of this gene is RAPGEF4.
Full Name
Rap Guanine Nucleotide Exchange Factor 3
Function
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Biological Process
Biological Process adaptive immune responseTAS:Reactome
Biological Process angiogenesisIEA:UniProtKB-KW
Biological Process associative learningIEA:Ensembl
Biological Process cAMP-mediated signaling1 PublicationNAS:BHF-UCL
Biological Process cellular response to cAMPManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of syncytium formation by plasma membrane fusionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein acetylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein export from nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of syncytium formation by plasma membrane fusionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rap protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process angiogenesisIEA:UniProtKB-KW
Biological Process associative learningIEA:Ensembl
Biological Process cAMP-mediated signaling1 PublicationNAS:BHF-UCL
Biological Process cellular response to cAMPManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of syncytium formation by plasma membrane fusionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein acetylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein export from nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of syncytium formation by plasma membrane fusionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rap protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Endomembrane system
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Anti-RAPGEF3 antibodies
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Target: RAPGEF3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 5D3
Application*: WB
Target: RAPGEF3
Host: Mouse
Specificity: Human, Rat, Hamster
Clone: CBCNR-207
Application*: WB, IH, IF, IP
Target: RAPGEF3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBCNR-206
Application*: WB, IP, P, ICC
Target: RAPGEF3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E5
Application*: E, WB
Target: RAPGEF3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBFYE-1614
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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