RAPGEF3

RAPGEF3 (Rap Guanine Nucleotide Exchange Factor 3) is a Protein Coding gene. Diseases associated with RAPGEF3 include Thrombocytopenia, Cyclic and Asthma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and cAMP-dependent protein kinase regulator activity. An important paralog of this gene is RAPGEF4.

Full Name

Rap Guanine Nucleotide Exchange Factor 3

Function

Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.

Biological Process

Biological Process adaptive immune responseTAS:Reactome
Biological Process angiogenesisIEA:UniProtKB-KW
Biological Process associative learningIEA:Ensembl
Biological Process cAMP-mediated signaling1 PublicationNAS:BHF-UCL
Biological Process cellular response to cAMPManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of syncytium formation by plasma membrane fusionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein acetylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein export from nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of syncytium formation by plasma membrane fusionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rap protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Endomembrane system