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Mouse Anti-RAPGEF3 Recombinant Antibody (CBCNR-207) (CBMAB-R1349-CN)

This product is a Mouse antibody that recognizes RAPGEF3. The antibody CBCNR-207 can be used for immunoassay techniques such as: WB, IHC, IF, IP.
See all RAPGEF3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Hamster
Clone
CBCNR-207
Application
WB, IHC, IF, IP

Basic Information

Specificity
Human, Rat, Hamster
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
> 1 mg/mL

Target

Full Name
Rap Guanine Nucleotide Exchange Factor 3
Introduction
RAPGEF3 (Rap Guanine Nucleotide Exchange Factor 3) is a Protein Coding gene. Diseases associated with RAPGEF3 include Thrombocytopenia, Cyclic and Asthma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and cAMP-dependent protein kinase regulator activity. An important paralog of this gene is RAPGEF4.
Entrez Gene ID
Human10411
Hamster100767619
Rat59326
UniProt ID
HumanO95398
HamsterA0A1U7Q409
RatQ9Z1C8
Alternative Names
Rap Guanine Nucleotide Exchange Factor 3; Exchange Protein Directly Activated By CAMP 1; Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By CAMP; CAMP-Regulated Guanine Nucleotide Exchange Factor I; Rap Guanine Nucleotide Exchange Factor (GEF) 3; Exchange Factor Directly Activated By CAMP 1; CAMP-GEFI; EPAC 1;
Function
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Biological Process
Biological Process adaptive immune responseTAS:Reactome
Biological Process angiogenesisIEA:UniProtKB-KW
Biological Process associative learningIEA:Ensembl
Biological Process cAMP-mediated signaling1 PublicationNAS:BHF-UCL
Biological Process cellular response to cAMPManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of syncytium formation by plasma membrane fusionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein acetylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein export from nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of syncytium formation by plasma membrane fusionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rap protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Endomembrane system
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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