RASSF2

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]

Full Name

Ras Association Domain Family Member 2

Function

Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

Biological Process

Biological Process bone remodelingIEA:Ensembl
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascadeIEA:Ensembl
Biological Process homeostasis of number of cellsIEA:Ensembl
Biological Process negative regulation of NIK/NF-kappaB signalingIEA:Ensembl
Biological Process negative regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Biological Process ossificationIEA:Ensembl
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:MGI
Biological Process positive regulation of JNK cascadeManual Assertion Based On ExperimentIDA:MGI
Biological Process positive regulation of protein autophosphorylationManual Assertion Based On ExperimentIDA:MGI
Biological Process positive regulation of protein kinase activityManual Assertion Based On ExperimentIDA:MGI
Biological Process protein stabilizationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of osteoblast differentiationIEA:Ensembl
Biological Process regulation of osteoclast differentiationIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process skeletal system developmentIEA:Ensembl

Cellular Location

Nucleus
Cytoplasm
Chromosome, centromere, kinetochore
Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.

PTM

Phosphorylated by STK3/MST2 and STK4/MST1.