RASSF5

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Ras association (RalGDS/AF-6) domain family member 5

Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process lymphocyte proliferationIEA:Ensembl
Biological Process negative regulation of lymphocyte proliferationIEA:Ensembl
Biological Process positive regulation of protein ubiquitinationIEA:Ensembl
Biological Process regulation of apoptotic processIEA:InterPro
Biological Process regulation of protein localization to nucleusIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm
Cytoplasm, cytoskeleton
Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.