Sign in or Register   Sign in or Register
  |  

Mouse Anti-RASSF5 Recombinant Antibody (1A11) (CBMAB-R1543-CN)

This product is a Mouse antibody that recognizes RASSF5. The antibody 1A11 can be used for immunoassay techniques such as: WB, FC.
See all RASSF5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A11
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Full length human recombinant protein of human RASSF5 (NP_872606) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
0.47 mg/mL

Target

Full Name
Ras association (RalGDS/AF-6) domain family member 5
Introduction
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
83593
UniProt ID
Q8WWW0
Alternative Names
Ras Association Domain Family Member 5; Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues; Ras Association (RalGDS/AF-6) Domain Family Member 5; Novel Ras Effector 1; New Ras Effector 1; NORE1; RAPL; Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissue; Ras Association (RalGDS/AF-6) Domain Family 5;
Function
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process lymphocyte proliferationIEA:Ensembl
Biological Process negative regulation of lymphocyte proliferationIEA:Ensembl
Biological Process positive regulation of protein ubiquitinationIEA:Ensembl
Biological Process regulation of apoptotic processIEA:InterPro
Biological Process regulation of protein localization to nucleusIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton
Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-RASSF5 Recombinant Antibody (1A11)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare