Mouse Anti-RASSF5 Recombinant Antibody (1A11) (CBMAB-R1543-CN)

Name: Mouse Anti-RASSF5 Recombinant Antibody (1A11)
SKU: CBMAB-R1543-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1A11

Application

WB, FC

Immunogen

Full length human recombinant protein of human RASSF5 (NP_872606) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

0.47 mg/mL

More Infomation

Target

Full Name

Ras association (RalGDS/AF-6) domain family member 5

Introduction

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

83593

UniProt ID

Q8WWW0

Alternative Names

Ras Association Domain Family Member 5; Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues; Ras Association (RalGDS/AF-6) Domain Family Member 5; Novel Ras Effector 1; New Ras Effector 1; NORE1; RAPL; Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissue; Ras Association (RalGDS/AF-6) Domain Family 5;

Function

Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process lymphocyte proliferationIEA:Ensembl
Biological Process negative regulation of lymphocyte proliferationIEA:Ensembl
Biological Process positive regulation of protein ubiquitinationIEA:Ensembl
Biological Process regulation of apoptotic processIEA:InterPro
Biological Process regulation of protein localization to nucleusIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton
Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-RASSF5 Recombinant Antibody (1C6) (CAT#: CBMAB-R1544-CN)

Mouse Anti-RASSF5 Recombinant Antibody (1H2) (CAT#: CBMAB-R1545-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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