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RCE1

This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. [provided by RefSeq]

Full Name

RCE1 homolog, prenyl protein peptidase (S. cerevisiae)

Function

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068).

Biological Process

Biological Process CAAX-box protein processingManual Assertion Based On ExperimentIDA:GO_Central
Biological Process MAPK cascadeTAS:Reactome
Biological Process protein prenylationManual Assertion Based On ExperimentIDA:GO_Central

Cellular Location

Endoplasmic reticulum membrane

PTM

Ubiquitinated. Undergoes 'Lys-48'- and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.

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Anti-RCE1 antibodies

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Mouse Anti-RCE1 Recombinant Antibody (CBCNR-348) (CBMAB-R1932-CN)

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Target: RCE1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBCNR-348

Application*: WB

Mouse Anti-RCE1 Recombinant Antibody (6A6) (CBMAB-R1931-CN)

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Target: RCE1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 6A6

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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