RCE1

This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. [provided by RefSeq]

Full Name

RCE1 homolog, prenyl protein peptidase (S. cerevisiae)

Function

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068).

Biological Process

Biological Process CAAX-box protein processingManual Assertion Based On ExperimentIDA:GO_Central
Biological Process MAPK cascadeTAS:Reactome
Biological Process protein prenylationManual Assertion Based On ExperimentIDA:GO_Central

Cellular Location

Endoplasmic reticulum membrane

PTM

Ubiquitinated. Undergoes 'Lys-48'- and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.

Anti-RCE1 antibodies

Mouse Anti-RCE1 Recombinant Antibody (CBCNR-348) (CBMAB-R1932-CN)

Datasheet

SDS

Target: RCE1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBCNR-348

Application*: WB

Mouse Anti-RCE1 Recombinant Antibody (6A6) (CBMAB-R1931-CN)

Datasheet

SDS

Target: RCE1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 6A6

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)