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Mouse Anti-RCE1 Recombinant Antibody (6A6) (CBMAB-R1931-CN)

This product is a Mouse antibody that recognizes RCE1. The antibody 6A6 can be used for immunoassay techniques such as: ELISA, WB.
See all RCE1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6A6
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 133-182 from RCE1 (NP_005124) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RCE1 homolog, prenyl protein peptidase (S. cerevisiae)
Introduction
This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. [provided by RefSeq, Jul 2008]
Entrez Gene ID
9986
UniProt ID
Q9Y256
Alternative Names
Ras Converting CAAX Endopeptidase 1; Prenyl Protein-Specific Endoprotease 2; Farnesylated Proteins-Converting Enzyme 2; Farnesylated Protein-Converting Enzyme 2; CAAX Prenyl Protease 2; RCE1A; RCE1B; FACE2; RCE1 Homolog, Prenyl Protein Peptidase (S. Cerevisiae);
Function
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068).
Biological Process
Biological Process CAAX-box protein processingManual Assertion Based On ExperimentIDA:GO_Central
Biological Process MAPK cascadeTAS:Reactome
Biological Process protein prenylationManual Assertion Based On ExperimentIDA:GO_Central
Cellular Location
Endoplasmic reticulum membrane
PTM
Ubiquitinated. Undergoes 'Lys-48'- and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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