Mouse Anti-RCE1 Recombinant Antibody (6A6) (CBMAB-R1931-CN)

Name: Mouse Anti-RCE1 Recombinant Antibody (6A6)
SKU: CBMAB-R1931-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

6A6

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa. 133-182 from RCE1 (NP_005124) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

RCE1 homolog, prenyl protein peptidase (S. cerevisiae)

Introduction

This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. [provided by RefSeq, Jul 2008]

Entrez Gene ID

9986

UniProt ID

Q9Y256

Alternative Names

Ras Converting CAAX Endopeptidase 1; Prenyl Protein-Specific Endoprotease 2; Farnesylated Proteins-Converting Enzyme 2; Farnesylated Protein-Converting Enzyme 2; CAAX Prenyl Protease 2; RCE1A; RCE1B; FACE2; RCE1 Homolog, Prenyl Protein Peptidase (S. Cerevisiae);

Function

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068).

Biological Process

Biological Process CAAX-box protein processingManual Assertion Based On ExperimentIDA:GO_Central
Biological Process MAPK cascadeTAS:Reactome
Biological Process protein prenylationManual Assertion Based On ExperimentIDA:GO_Central

Cellular Location

Endoplasmic reticulum membrane

PTM

Ubiquitinated. Undergoes 'Lys-48'- and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-RCE1 Recombinant Antibody (CBCNR-348) (CAT#: CBMAB-R1932-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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