RGS2

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq]

Full Name

regulator of G-protein signaling 2, 24kDa

Function

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087).
It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619).
Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity).
Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).

Biological Process

Biological Process brain developmentIEA:Ensembl
Biological Process brown fat cell differentiationIEA:Ensembl
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process maternal process involved in female pregnancyIEA:Ensembl
Biological Process negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart processISS:BHF-UCL
Biological Process negative regulation of cardiac muscle hypertrophyISS:BHF-UCL
Biological Process negative regulation of cell growth involved in cardiac muscle cell developmentIEA:Ensembl
Biological Process negative regulation of G protein-coupled receptor signaling pathwayISS:BHF-UCL
Biological Process negative regulation of glycine import across plasma membraneIEA:Ensembl
Biological Process negative regulation of MAP kinase activityISS:BHF-UCL
Biological Process negative regulation of phospholipase activityISS:BHF-UCL
Biological Process negative regulation of translationIEA:Ensembl
Biological Process ovulationIEA:Ensembl
Biological Process positive regulation of cardiac muscle contractionISS:BHF-UCL
Biological Process positive regulation of neuron projection developmentIEA:Ensembl
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process relaxation of cardiac muscleISS:BHF-UCL
Biological Process relaxation of vascular associated smooth muscleIEA:Ensembl
Biological Process response to amphetamineIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process spermatogenesisIEA:Ensembl

Cellular Location

Isoform 1
Cell membrane
Cytoplasm
Nucleus, nucleolus
Isoform 2
Cell membrane
Cytoplasm
Nucleus, nucleolus
Isoform 3
Cell membrane
Cytoplasm
Nucleus, nucleolus
Isoform 4
Cell membrane
Mitochondrion

PTM

Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.