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Mouse Anti-RGS2 Recombinant Antibody (4C4) (CBMAB-R2449-CN)

This product is a Mouse antibody that recognizes RGS2. The antibody 4C4 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all RGS2 antibodies
Published Data
Fig.1 Induction of RGS2 expression by cAMP and PDD and RGS2 translocation from nucleus to cytosol by PDD.
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Fig.2 PKA- and PKC-induced RGS2 expression.
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Fig.3 Knockdown efficiencies of target proteins in HEK293 cells measured by Reverse Phase Protein Array (RPPA) and Western blotting.
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Fig.4 RGS2 blocked Pam3CSK4-stimulated STAT3 phosphorylation.
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Fig.5 RGS2 is a negative regulator of TLR2-mediated Nox1 expression.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4C4
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 111-211, from human RGS2 (H07049) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
regulator of G-protein signaling 2, 24kDa
Introduction
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]
Entrez Gene ID
5997
UniProt ID
P41220
Alternative Names
Regulator Of G Protein Signaling 2; Regulator Of G-Protein Signaling 2, 24kDa; Cell Growth-Inhibiting Gene 31 Protein; Regulator Of G-Protein Signaling 2; G0/G1 Switch Regulatory Protein 8; G0S8;
Function
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087).
It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619).
Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity).
Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).
Biological Process
Biological Process brain developmentIEA:Ensembl
Biological Process brown fat cell differentiationIEA:Ensembl
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process maternal process involved in female pregnancyIEA:Ensembl
Biological Process negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart processISS:BHF-UCL
Biological Process negative regulation of cardiac muscle hypertrophyISS:BHF-UCL
Biological Process negative regulation of cell growth involved in cardiac muscle cell developmentIEA:Ensembl
Biological Process negative regulation of G protein-coupled receptor signaling pathwayISS:BHF-UCL
Biological Process negative regulation of glycine import across plasma membraneIEA:Ensembl
Biological Process negative regulation of MAP kinase activityISS:BHF-UCL
Biological Process negative regulation of phospholipase activityISS:BHF-UCL
Biological Process negative regulation of translationIEA:Ensembl
Biological Process ovulationIEA:Ensembl
Biological Process positive regulation of cardiac muscle contractionISS:BHF-UCL
Biological Process positive regulation of neuron projection developmentIEA:Ensembl
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process relaxation of cardiac muscleISS:BHF-UCL
Biological Process relaxation of vascular associated smooth muscleIEA:Ensembl
Biological Process response to amphetamineIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process spermatogenesisIEA:Ensembl
Cellular Location
Isoform 1
Cell membrane
Cytoplasm
Nucleus, nucleolus
Isoform 2
Cell membrane
Cytoplasm
Nucleus, nucleolus
Isoform 3
Cell membrane
Cytoplasm
Nucleus, nucleolus
Isoform 4
Cell membrane
Mitochondrion
PTM
Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
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For research use only. Not intended for any clinical use.

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