RHOF

RHOF (Ras Homolog Family Member F, Filopodia Associated) is a Protein Coding gene. Diseases associated with RHOF include Charcot-Marie-Tooth Disease, Axonal, Type 2L and Malaria. Among its related pathways are Innate Immune System and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOD.

Full Name

Ras Homolog Family Member F, Filopodia Associated

Function

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.

Biological Process

Biological Process actin filament organizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cortical cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of small GTPase mediated signal transductionTAS:Reactome
Biological Process small GTPase mediated signal transductionIEA:InterPro

Cellular Location

Cell membrane
Cytoplasm, cytoskeleton