RIC8A

RIC8A (RIC8 Guanine Nucleotide Exchange Factor A) is a Protein Coding gene. Diseases associated with RIC8A include Walker-Warburg Syndrome. Gene Ontology (GO) annotations related to this gene include binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIC8B.

Full Name

resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)

Function

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity).
Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Biological Process

Biological Process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process basement membrane organizationIEA:Ensembl
Biological Process cell migration involved in gastrulationIEA:Ensembl
Biological Process cell-cell adhesion involved in gastrulationIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process vasculature developmentIEA:Ensembl
Biological Process visual learningIEA:Ensembl

Cellular Location

Cytoplasm
Cell membrane
Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity).