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Mouse Anti-RIC8A Recombinant Antibody (CBCNR-496) (CBMAB-R2620-CN)

This product is a Mouse antibody that recognizes RIC8A. The antibody CBCNR-496 can be used for immunoassay techniques such as: WB, ELISA, WB.
See all RIC8A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-496
Antibody Isotype
IgG2a, κ
Application
WB, ELISA, WB

Basic Information

Immunogen
RIC8A (NP_068751.4, aa. 462-534) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1× PBS, pH 7.2

Target

Full Name
resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
Introduction
RIC8A (RIC8 Guanine Nucleotide Exchange Factor A) is a Protein Coding gene. Diseases associated with RIC8A include Walker-Warburg Syndrome. Gene Ontology (GO) annotations related to this gene include binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIC8B.
Entrez Gene ID
60626
UniProt ID
Q9NPQ8
Alternative Names
RIC8 Guanine Nucleotide Exchange Factor A; Resistance To Inhibitors Of Cholinesterase 8 Homolog A (C. Elegans); Resistance To Inhibitors Of Cholinesterase 8 Homolog A; Protein Ric-8A; Synembryn-A; RIC8;
Function
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity).
Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Biological Process
Biological Process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process basement membrane organizationIEA:Ensembl
Biological Process cell migration involved in gastrulationIEA:Ensembl
Biological Process cell-cell adhesion involved in gastrulationIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process vasculature developmentIEA:Ensembl
Biological Process visual learningIEA:Ensembl
Cellular Location
Cytoplasm
Cell membrane
Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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