RIN1

RIN1 (Ras And Rab Interactor 1) is a Protein Coding gene. Diseases associated with RIN1 include Bladder Urothelial Carcinoma. Among its related pathways are Vesicle-mediated transport and ErbB1 downstream signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Ras GTPase binding. An important paralog of this gene is RIN2.

Full Name

Ras And Rab Interactor 1

Function

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Biological Process

Biological Process endocytosisIEA:UniProtKB-KW
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm
Membrane
Cytoplasm, cytoskeleton
Some amount is membrane-associated.

PTM

Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins.