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Mouse Anti-RIN1 Recombinant Antibody (1D11) (CBMAB-R2671-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1D11
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa. 646-755 from RIN1 (H14417) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
Ras And Rab Interactor 1
Introduction
RIN1 (Ras And Rab Interactor 1) is a Protein Coding gene. Diseases associated with RIN1 include Bladder Urothelial Carcinoma. Among its related pathways are Vesicle-mediated transport and ErbB1 downstream signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Ras GTPase binding. An important paralog of this gene is RIN2.
Entrez Gene ID
9610
UniProt ID
Q13671
Alternative Names
Ras And Rab Interactor 1; Ras Interaction/Interference Protein 1; Ras Inhibitor JC99;
Function
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
Biological Process
Biological Process endocytosisIEA:UniProtKB-KW
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Membrane
Cytoplasm, cytoskeleton
Some amount is membrane-associated.
PTM
Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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