RNF4

The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]

Full Name

Ring Finger Protein 4

Function

E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

Biological Process

Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of transcription, DNA-templatedISS:UniProtKB
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein autoubiquitinationISS:UniProtKB
Biological Process protein K11-linked ubiquitinationISS:UniProtKB
Biological Process protein K48-linked ubiquitinationISS:UniProtKB
Biological Process protein K6-linked ubiquitinationISS:UniProtKB
Biological Process protein K63-linked ubiquitinationISS:UniProtKB
Biological Process regulation of kinetochore assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to arsenic-containing substanceManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Nucleus, PML body
Nucleus, nucleoplasm

PTM

Sumoylated; conjugated by one or two SUMO1 moieties.
Autoubiquitinated.