RPH3A

The protein encoded by this gene is thought to be an effector for RAB3A, which is a small G protein that acts in the late stages of neurotransmitter exocytosis. The encoded protein may be involved in neurotransmitter release and synaptic vesicle traffic. [provided by RefSeq, Dec 2016]

Full Name

Rabphilin 3A

Function

Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity).
At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity).
In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity).

Biological Process

Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportIEA:InterPro
Biological Process regulation of calcium ion-dependent exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spontaneous neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Cell projection, dendritic spine
Postsynaptic cell membrane
Membrane

PTM

Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation.