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Mouse Anti-RPH3A Recombinant Antibody (M370) (CBMAB-R3336-CN)

This product is a Mouse antibody that recognizes RPH3A. The antibody M370 can be used for immunoassay techniques such as: WB, ELISA, IHC.
See all RPH3A antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
M370
Antibody Isotype
IgG1
Application
WB, ELISA, IHC

Basic Information

Specificity
Human, Rat, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Rabphilin 3A
Introduction
The protein encoded by this gene is thought to be an effector for RAB3A, which is a small G protein that acts in the late stages of neurotransmitter exocytosis. The encoded protein may be involved in neurotransmitter release and synaptic vesicle traffic. [provided by RefSeq, Dec 2016]
Entrez Gene ID
Human22895
Mouse19894
Rat171039
UniProt ID
HumanQ9Y2J0
MouseP47708
RatP47709
Alternative Names
Rabphilin 3A; Exophilin-1; Rabphilin 3A Homolog (Mouse); Rabphilin 3A Homolog; Rabphilin-3A; KIAA0985;
Function
Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity).
At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity).
In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity).
Biological Process
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportIEA:InterPro
Biological Process regulation of calcium ion-dependent exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spontaneous neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Cell projection, dendritic spine
Postsynaptic cell membrane
Membrane
PTM
Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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