RPL23A

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Full Name

ribosomal protein L23a

Function

Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547).
Binds a specific region on the 26S rRNA (PubMed:23636399, PubMed:32669547).
May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195).

Biological Process

Biological Process cytoplasmic translation1 PublicationIC:FlyBase
Biological Process ribosomal large subunit assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process translation2 PublicationsNAS:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Although RPL23A is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL23A nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn.

PTM

N-terminus is methylated by METTL11A/NTM1.
Citrullinated by PADI4.