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Mouse Anti-RPL23A Recombinant Antibody (3E11) (CBMAB-R3373-CN)

This product is a Mouse antibody that recognizes RPL23A. The antibody 3E11 can be used for immunoassay techniques such as: ELISA, WB.
See all RPL23A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E11
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 59-157 from human RPL23A (NP_000975) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
ribosomal protein L23a
Introduction
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Entrez Gene ID
6147
UniProt ID
P62750
Alternative Names
Ribosomal Protein L23a; Large Ribosomal Subunit Protein UL23; Melanoma Differentiation-Associated Gene 20; 0S Ribosomal Protein L23a; MDA20; L23a;
Function
Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547).
Binds a specific region on the 26S rRNA (PubMed:23636399, PubMed:32669547).
May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195).
Biological Process
Biological Process cytoplasmic translation1 PublicationIC:FlyBase
Biological Process ribosomal large subunit assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process translation2 PublicationsNAS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Although RPL23A is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL23A nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn.
PTM
N-terminus is methylated by METTL11A/NTM1.
Citrullinated by PADI4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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