RPLP0

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq]

Full Name

ribosomal protein, large, P0

Function

Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

Biological Process

Biological Process cellular response to cAMPIEA:Ensembl
Biological Process cellular response to interleukin-4IEA:Ensembl
Biological Process cellular response to phorbol 13-acetate 12-myristateIEA:Ensembl
Biological Process cellular response to Thyroid stimulating hormoneIEA:Ensembl
Biological Process cytoplasmic translationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process lactationIEA:Ensembl
Biological Process response to selenium ionIEA:Ensembl
Biological Process ribosomal large subunit assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process translation1 PublicationNAS:UniProtKB

Cellular Location

Nucleus
Cytoplasm
Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:19188445, PubMed:17289661).