RREB1

The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Full Name

Ras Responsive Element Binding Protein 1

Function

Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:9305772, PubMed:15067362, PubMed:8816445, PubMed:10390538, PubMed:17550981).
Represses the angiotensinogen gene (PubMed:15067362).
Negatively regulates the transcriptional activity of AR (PubMed:17550981).
Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979).
Promotes brown adipocyte differentiation (By similarity).
May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445).

Biological Process

Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of brown fat cell differentiationISS:UniProtKB
Biological Process positive regulation of DNA-templated transcriptionManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of lamellipodium morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of mammary gland epithelial cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Biological Process positive regulation of wound healing, spreading of epidermal cellsManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus speckle