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Mouse Anti-RREB1 Recombinant Antibody (2939C1a) (CBMAB-R3658-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2939C1a
Antibody Isotype
IgG1
Application
Dot

Basic Information

Immunogen
Recombinant human Ras Responsive Element Binding Protein 1 (Rreb1)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 1% BSA
Preservative
0.05% Sodium azide
Concentration
0.1 mg/mL
Purity
>95% (SDS-PAGE)

Target

Full Name
Ras Responsive Element Binding Protein 1
Introduction
The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Entrez Gene ID
6239
UniProt ID
Q92766
Alternative Names
Ras Responsive Element Binding Protein 1; Zinc Finger Motif Enhancer-Binding Protein 1; Raf-Responsive Zinc Finger Protein LZ321; Finger Protein In Nuclear Bodies; RREB-1; Zep-1; FINB;
Function
Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:9305772, PubMed:15067362, PubMed:8816445, PubMed:10390538, PubMed:17550981).
Represses the angiotensinogen gene (PubMed:15067362).
Negatively regulates the transcriptional activity of AR (PubMed:17550981).
Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979).
Promotes brown adipocyte differentiation (By similarity).
May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445).
Biological Process
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of brown fat cell differentiationISS:UniProtKB
Biological Process positive regulation of DNA-templated transcriptionManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of lamellipodium morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of mammary gland epithelial cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Biological Process positive regulation of wound healing, spreading of epidermal cellsManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus speckle
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For research use only. Not intended for any clinical use.

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