RSPO3

This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]
Full Name
R-Spondin 3
Function
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920).
Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) (PubMed:21727895, PubMed:21909076, PubMed:22615920).
Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (PubMed:29769720).
Biological Process
Biological Process blood vessel remodelingISS:UniProtKB
Biological Process branching involved in labyrinthine layer morphogenesisIEA:Ensembl
Biological Process canonical Wnt signaling pathwayIEA:Ensembl
Biological Process positive regulation of canonical Wnt signaling pathwayIEA:Ensembl
Biological Process positive regulation of non-canonical Wnt signaling pathwayISS:UniProtKB
Biological Process positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of Wnt signaling pathway, planar cell polarity pathwayManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process sprouting angiogenesisISS:UniProtKB
Cellular Location
Secreted
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Anti-RSPO3 antibodies

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Human Recombinant RSPO3 protein, His Tag-2 (V2LY-0526-LY6629)

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Target: RSPO3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 33-272
Tag: His Tag
Datasheet SDS

Human Recombinant RSPO3 protein, His Tag-1 (V2LY-0526-LY6628)

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Target: RSPO3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 33-272
Tag: His Tag
Datasheet SDS

Human Recombinant RSPO3 protein, His Tag (V2LY-0526-LY6627)

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Target: RSPO3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-146
Tag: His Tag
Datasheet SDS

Rat Anti-RSPO3 Recombinant Antibody (7H222) (CBMAB-R3754-CN)

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Target: RSPO3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 7H222
Application*: E, WB
Datasheet SDS

Mouse Anti-RSPO3 Recombinant Antibody (4G10) (CBMAB-R3753-CN)

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Target: RSPO3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4G10
Application*: WB
Datasheet SDS

Rat Anti-RSPO3 Recombinant Antibody (400404) (CBMAB-R3752-CN)

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Target: RSPO3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 400404
Application*: WB
Datasheet SDS

Rat Anti-RSPO3 Recombinant Antibody (400403) (CBMAB-R3751-CN)

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Target: RSPO3
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 400403
Application*: WB
Datasheet SDS

Mouse Anti-RSPO3 Recombinant Antibody (3D5) (CBMAB-R3750-CN)

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Target: RSPO3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D5
Application*: IH
Datasheet SDS

Mouse Anti-RSPO3 Recombinant Antibody (3A9) (CBMAB-R3749-CN)

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Target: RSPO3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A9
Application*: WB, IH
Datasheet SDS

Mouse Anti-RSPO3 Recombinant Antibody (1E4F1) (CBMAB-R3748-CN)

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Target: RSPO3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1E4F1
Application*: E, WB, IH, IF
Datasheet SDS

Rat Anti-RSPO3 Recombinant Antibody (15H133) (CBMAB-R3747-CN)

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Target: RSPO3
Host: Rat
Specificity: Mouse
Clone: 15H133
Application*: WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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