Mouse Rspo3 ELISA Kit (V2LY-0626-LY3006)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.00097 ng/mL
Detection Range
0.002-0.6 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
31.5 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
R-Spondin 3
Function
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920).
Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) (PubMed:21727895, PubMed:21909076, PubMed:22615920).
Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (PubMed:29769720).
Biological Process
Biological Process blood vessel remodelingISS:UniProtKB
Biological Process branching involved in labyrinthine layer morphogenesisIEA:Ensembl
Biological Process canonical Wnt signaling pathwayIEA:Ensembl
Biological Process positive regulation of canonical Wnt signaling pathwayIEA:Ensembl
Biological Process positive regulation of non-canonical Wnt signaling pathwayISS:UniProtKB
Biological Process positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of Wnt signaling pathway, planar cell polarity pathwayManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process sprouting angiogenesisISS:UniProtKB
Cellular Location
Secreted
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant RSPO3 protein, His Tag (CAT#: V2LY-0526-LY6627)

Human Recombinant RSPO3 protein, His Tag-1 (CAT#: V2LY-0526-LY6628)

Human Recombinant RSPO3 protein, His Tag-2 (CAT#: V2LY-0526-LY6629)

Related Products

Rat Anti-RSPO3 Recombinant Antibody (7H222) (CAT#: CBMAB-R3754-CN)

Mouse Anti-RSPO3 Recombinant Antibody (1E4F1) (CAT#: CBMAB-R3748-CN)

Mouse Anti-RSPO3 Recombinant Antibody (3D5) (CAT#: CBMAB-R3750-CN)

Mouse Anti-RSPO3 Recombinant Antibody (3A9) (CAT#: CBMAB-R3749-CN)

Human Recombinant RSPO3 protein, His Tag-1 (CAT#: V2LY-0526-LY6628)

Rat Anti-RSPO3 Recombinant Antibody (400404) (CAT#: CBMAB-R3752-CN)

Human Recombinant RSPO3 protein, His Tag (CAT#: V2LY-0526-LY6627)

Human Recombinant RSPO3 protein, His Tag-2 (CAT#: V2LY-0526-LY6629)

Rat Anti-RSPO3 Recombinant Antibody (15H133) (CAT#: CBMAB-R3747-CN)

Mouse Anti-RSPO3 Recombinant Antibody (4G10) (CAT#: CBMAB-R3753-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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