S. cerevisiae CDC28

This protein is essential for the completion of the start, the controlling event, in the cell cycle. More than 200 substrates have been identified.

cyclin-dependent serine/threonine-protein kinase CDC28

Cyclin-dependent kinase that acts as a master regulator of the mitotic and meiotic cell cycles (By similarity).
Required to drive the G1-S transition (PubMed:2664468).
More than 200 substrates have been identified (PubMed:14574415).
Substrate specificity is in part regulated by the bound cyclin protein (By similarity).
Phosphorylates YTA7 during S-phase to promote transcription of histones (PubMed:22156209).

Biological Process 7-methylguanosine mRNA cappingManual Assertion Based On ExperimentIMP:SGD
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process DNA double-strand break processingManual Assertion Based On ExperimentIMP:SGD
Biological Process double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIMP:SGD
Biological Process G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process G2/M transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process meiotic DNA double-strand break processingManual Assertion Based On ExperimentIGI:SGD
Biological Process mitotic sister chromatid biorientationManual Assertion Based On ExperimentIGI:SGD
Biological Process mitotic spindle assemblyManual Assertion Based On ExperimentIGI:SGD
Biological Process negative regulation of DNA replication origin bindingManual Assertion Based On ExperimentIGI:SGD
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:SGD
Biological Process negative regulation of double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIMP:SGD
Biological Process negative regulation of meiotic cell cycleManual Assertion Based On ExperimentIMP:SGD
Biological Process negative regulation of mitotic actomyosin contractile ring assemblyManual Assertion Based On ExperimentIMP:SGD
Biological Process negative regulation of mitotic cell cycleManual Assertion Based On ExperimentIDA:SGD
Biological Process negative regulation of sister chromatid cohesionManual Assertion Based On ExperimentIMP:SGD
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:SGD
Biological Process positive regulation of double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of glycogen catabolic processManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of meiotic cell cycleManual Assertion Based On ExperimentIDA:SGD
Biological Process positive regulation of mitotic cell cycleManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of mitotic DNA damage checkpointManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of mitotic spindle pole body separationManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of nuclear cell cycle DNA replicationManual Assertion Based On ExperimentIDA:SGD
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of trehalose catabolic processManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of triglyceride catabolic processManual Assertion Based On ExperimentIMP:SGD
Biological Process post-Golgi vesicle-mediated transportManual Assertion Based On ExperimentIMP:SGD
Biological Process protein catabolic processManual Assertion Based On ExperimentIMP:SGD
Biological Process protein localization to nuclear peripheryManual Assertion Based On ExperimentIMP:SGD
Biological Process protein localization to nucleusManual Assertion Based On ExperimentIMP:SGD
Biological Process protein localization to spindle microtubuleManual Assertion Based On ExperimentIMP:SGD
Biological Process protein phosphorylationManual Assertion Based On ExperimentIDA:CACAO
Biological Process regulation of budding cell apical bud growthManual Assertion Based On ExperimentIMP:SGD
Biological Process regulation of cell cycle G1/S phase transition1 PublicationIC:ComplexPortal
Biological Process regulation of chromatin organizationManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process regulation of filamentous growthManual Assertion Based On ExperimentIMP:SGD
Biological Process regulation of G2/M transition of mitotic cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of protein localizationManual Assertion Based On ExperimentIMP:SGD
Biological Process regulation of protein localization to chromatinManual Assertion Based On ExperimentIDA:SGD
Biological Process regulation of spindle assemblyManual Assertion Based On ExperimentIMP:SGD
Biological Process regulation of telomere maintenance via telomeraseManual Assertion Based On ExperimentIGI:SGD
Biological Process regulation of transcription involved in G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synaptonemal complex assemblyManual Assertion Based On ExperimentIMP:SGD
Biological Process telomere maintenanceManual Assertion Based On ExperimentIDA:SGD

cellular bud neck
cyclin-dependent protein kinase holoenzyme complex
cytoplasm
cytoplasmic stress granule
endoplasmic reticulum
nucleus