S100P
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer.
Full Name
S100 Calcium Binding Protein P
Function
May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).
Biological Process
Biological Process endothelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to organic substanceManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process response to organic substanceManual Assertion Based On ExperimentIEP:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Cell projection, microvillus membrane
Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.
Cytoplasm
Cell projection, microvillus membrane
Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.
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Anti-S100P antibodies
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Target: S100P
Host: Mouse
Specificity: Human
Clone: IHC658
Application*: IH
Target: S100P
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4E7
Application*: WB, E
Target: S100P
Host: Mouse
Specificity: Human
Clone: CBXS-2661
Application*: E, IF, WB
Target: S100P
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1795
Application*: WB, IC
Target: S100P
Host: Mouse
Specificity: Human
Clone: CBXS-0097
Application*: WB, IC, P, C, E
Target: S100P
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0096
Application*: E, WB
Target: S100P
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-5049
Application*: E, IF, WB
Target: S100P
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-4256
Application*: F
Target: S100P
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4090
Application*: WB
Target: S100P
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBXS-3812
Application*: WB, IF
Target: S100P
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-3748
Application*: IH
Target: S100P
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-3116
Application*: P
Target: S100P
Expressed Host: E. coli
Sequence: Amino Acid: 1-95
Target: S100P
Expressed Host: E. coli
Sequence: Amino Acid: 1-95
Target: S100P
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYR-0041
Application*: ELISA
Target: S100P
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1A11
Application*: WB, E, IF
Target: S100P
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4E7.
Application*: WB, E, IF
Target: S100P
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 1A4
Application*: WB, IF
Target: S100P
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 357517
Application*: WB, IC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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