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Mouse Anti-S100P Recombinant Antibody (IHC658) (CBMAB-MA215-YC)

Provided herein is a Mouse monoclonal antibody against S100 Calcium Binding Protein P. The antibody can be used for immunoassay techniques, such as IHC. And it gave a positive signal in Pancreatic Ductal Adenocarcinoma and Urothelial Carcinoma, Placenta.
See all S100P antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
IHC658
Application
IHC (1:100 - 1:200)

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Tris buffer pH 7.3 - 7.7, 1% BSA, < 0.1% Sodium Azide
Storage
Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

Target

Full Name
S100 Calcium Binding Protein P
Introduction
S100P is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer.
Entrez Gene ID
6286
UniProt ID
P25815
Alternative Names
S100 Calcium Binding Protein P; Migration-Inducing Gene 9 Protein; S100 Calcium-Binding Protein P; Protein S100-E; MIG9; Protein S100-P; S100E;
Function
May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).
Biological Process
Biological Process endothelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to organic substanceManual Assertion Based On ExperimentIEP:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Cell projection, microvillus membrane
Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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