SARS-CoV-2 N

The newly identified 2019 novel coronavirus (SARS-CoV-2) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health.
Full Name
SARS-CoV-2 N
Function
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (By similarity).
May induce inflammasome responses in cultured cells and mice. Acts by interacting with host NLRP3 to facilitate inflammasome assembly, which induces cytokine release that may play a role in COVID lung injury.
Biological Process
Biological Process negative regulation of interferon-beta productionManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process positive regulation of NLRP3 inflammasome complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to host immune responseManual Assertion Based On ExperimentIDA:DisProt
Biological Process viral RNA genome packaging1 PublicationIC:ComplexPortal
Cellular Location
Virion
Host cytoplasm
Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
PTM
ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
Phosphorylated on serine residues by host GSK3A and GSK3B.
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Anti-SARS-CoV-2 N antibodies

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SARS-CoV-2 N Matched Antibody Pair (NB2) (APMAB-1339LY)

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Target: SARS-CoV-2 N
Specificity: SARS
Datasheet SDS

SARS-CoV-2 N Matched Antibody Pair (NB1) (APMAB-1338LY)

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Target: SARS-CoV-2 N
Specificity: SARS
Datasheet SDS

Human Anti-SARS-CoV-2 N Recombinant IgM Antibody (M01) (CBMAB-CR008LY)

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Target: SARS-CoV-2 N
Host: Human
Antibody Isotype: IgM
Specificity: SARS Coronavirus, SARS Coronavirus 2
Clone: M01
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-SARS-CoV-2 N Recombinant Antibody (CBC02) (CBMAB-CR002LY)

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Target: SARS-CoV-2 N
Host: Mouse
Antibody Isotype: IgG1
Specificity: SARS Coronavirus, SARS Coronavirus 2
Clone: CBC002
Application*: WB, ICC/IF
Datasheet SDS

Human Anti-SARS-CoV-2 N Monoclonal Antibody (CBFYR-0118) (CBMAB-R0118-FY)

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Target: SARS-CoV-2 N
Host: Human
Antibody Isotype: IgG
Specificity: 2019 Novel Coronavirus
Clone: CBFYR-0118
Application*: ELISA, WB
Datasheet SDS

Human Anti-SARS-CoV-2 N Monoclonal Antibody (CBFYR-0117) (CBMAB-R0117-FY)

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Target: SARS-CoV-2 N
Host: Human
Antibody Isotype: IgG
Specificity: 2019 Novel Coronavirus
Clone: CBFYR-0117
Application*: ELISA, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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