SCARA5

SCARA5 (Scavenger Receptor Class A Member 5) is a Protein Coding gene. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity and ferritin receptor activity. An important paralog of this gene is MSR1.

Full Name

Scavenger Receptor Class A Member 5

Function

Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Preferentially binds ferritin light chain (FTL) compared to heavy chain (FTH1).

Biological Process

Biological Process cellular iron ion homeostasisISS:UniProtKB
Biological Process cellular response to heatIEA:Ensembl
Biological Process endocytosisISS:UniProtKB
Biological Process iron ion transmembrane transportISS:UniProtKB
Biological Process protein homotrimerizationISS:UniProtKB

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-60
Helical: 61-81
Extracellular: 82-495